Macrophages loaded with gold nanoshells for photothermal ablation of glioma: An in vitro model
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Modified Photochemical Properties of Mitoxantrone by Plasmonic Photothermal Response of Hollow Gold Nanoshells
Introduction: Mitoxantrone (MX) has been introduced as a photosensitizer drug. However, due to some side effects, the widespread use of this drug has been confronted with some limitations. Hollow gold nanoshells (HGN) have attracted considerable attention due to their interesting photochemical features that can use as nanocarrier. In this paper, the thermal response of MX and the use of this pr...
متن کاملCombined concurrent photodynamic and gold nanoshell loaded macrophage-mediated photothermal therapies: an in vitro study on squamous cell head and neck carcinoma.
BACKGROUND AND OBJECTIVE Treatment modalities, such as hyperthermia and photodynamic therapy (PDT) have been used in the treatment of a variety of head and neck squamous cell carcinoma (HNSCC), either alone or as an adjuvant therapy. Macrophages loaded with gold nanoshells, which convert near-infrared light to heat, can be used as transport vectors for photothermal hyperthermia of tumors. The p...
متن کاملPhotothermal enhancement of chemotherapy mediated by gold-silica nanoshell-loaded macrophages: in vitro squamous cell carcinoma study.
Moderate hyperthermia (MHT) has been shown to enhance the effects of chemotherapeutic agents in a wide variety of cancers. The purpose of this study was to investigate the combined effects of commonly used chemotherapeutic agents with MHT induced by near-infrared (NIR) activation of gold nanoshell (AuNS)-loaded macrophages (Ma). AuNS-loaded murine Ma combined with human FaDu squamous cells, in ...
متن کاملNear-infrared-activated gold nanoshells for thermal ablation of macrophages in vitro
In vitro studies were initiated to determine the suitability of murine and rat macrophages as delivery vehicles for gold nanoshells in the treatment of gliomas. Visualization of macrophage accumulation in and around gliomas may be accomplished using magnetic resonance imaging (MRI) and superparamagnetic iron oxide nanoparticles (SPIO). The optimal loading of both murine and rat macrophages with...
متن کاملIn Vitro Investigation into Plasmonic Photothermal Effect of Hollow Gold Nanoshell Irradiated with Incoherent Light
Introduction: Hollow gold nanoshells (HAuNS) are one of the most attractive nanostructures for biomedical applications due to their interesting physicochemical properties. This study sought to evaluate the plasmonic photothermal effect of HAuNS irradiated with incoherent light on melanoma cell line. Materials and Methods: After the synthesis of nanostructures, the temperature changes of HAuNS ...
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